Like regularly changing the batteries in you smoke detector, a periodic home 
inspection of you heating and cooling system is always a good idea.   
 Aesthetically changing the vents, registers and grilles because of room 
dynamics is one thing, but watch out for the obvious.  Register or "damper" 
failure due to dust, grit or rust should certainly be looked into.
I hope the information and links below will help you understand and be aware 
of the "ins and outs" of your heating and cooling system.
  
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    | A Typical Residential Heating and Cooling System | 
You should consider having the air ducts in your home cleaned if:
  There is substantial visible mold growth inside hard surface (e.g., sheet 
  metal) ducts or on other components of your heating and cooling system. There 
  are several important points to understand concerning mold detection in 
  heating and cooling systems:
  
    - Many sections of your heating and cooling system may not be accessible 
    for a visible inspection, so ask the service provider to show you any mold 
    they say exists. 
- You should be aware that although a substance may look like mold, a 
    positive determination of whether it is mold or not can be made only by an 
    expert and may require laboratory analysis for final confirmation. For about 
    $50, some microbiology laboratories can tell you whether a sample sent to 
    them on a clear strip of sticky household tape is mold or simply a substance 
    that resembles it. 
- If you have insulated air ducts and the insulation gets wet or moldy it 
    cannot be effectively cleaned and should be removed and replaced. 
- If the conditions causing the mold growth in the first place are not 
    corrected, mold growth will recur. 
Ducts are infested with vermin, e.g. (rodents or insects); or
  Ducts are clogged with excessive amounts of dust and debris and/or 
  particles are actually released into the home from your supply registers.
Other Important Considerations...
Duct cleaning has never been shown to actually prevent health 
problems. Neither do studies conclusively demonstrate that particle (e.g., dust) 
levels in homes increase because of dirty air ducts or go down after cleaning. 
This is because much of the dirt that may accumulate inside air ducts adheres to 
duct surfaces and does not necessarily enter the living space. It is important 
to keep in mind that dirty air ducts are only one of many possible sources of 
particles that are present in homes. Pollutants that enter the home both from 
outdoors and indoor activities such as cooking, cleaning, smoking, or just 
moving around can cause greater exposure to contaminants than dirty air ducts. 
Moreover, there is no evidence that a light amount of household dust or other 
particulate matter in air ducts poses any risk to health.
EPA does not recommend that air ducts be cleaned except on an 
as-needed basis because of the continuing uncertainty about the benefits of duct 
cleaning under most circumstances. If a service provider or advertiser asserts 
that EPA recommends routine duct cleaning or makes claims about its health 
benefits, you should notify EPA by writing to the address listed at the end of 
this guidance. EPA does, however, recommend that if you have a fuel burning 
furnace, stove, or fireplace, they be inspected for proper functioning and 
serviced before each heating season to protect against carbon monoxide 
poisoning. Some research also suggests that cleaning dirty cooling coils, fans 
and heat exchangers can improve the efficiency of heating and cooling systems. 
However, little evidence exists to indicate that simply cleaning the duct system 
will increase your system's efficiency.
If you think duct cleaning might be a good idea for your home, but you are 
not sure, talk to a professional. The company that services your heating and 
cooling system may be a good source of advice. You may also want to contact 
professional duct cleaning service providers and ask them about the services 
they provide. Remember, they are trying to sell you a service, so ask questions 
and insist on complete and knowledgeable answers.
 
  
    | Consumer Checklist | 
  
    |  | Learn as much as possible about air duct cleaning before 
    you decide to have your ducts cleaned by reading this guidance and 
    contacting the sources of information provided. | 
  
    |  | Consider other possible sources of indoor 
    air pollution first if you suspect an indoor air quality problem exists in 
    your home. | 
  
    |  | Have your air ducts cleaned if they are visibly 
    contaminated with substantial mold growth, pests or vermin, or are clogged 
    with substantial deposits of dust or debris. | 
  
    |  | Ask the service provider to show you any mold or other 
    biological contamination they say exists. Get laboratory confirmation of 
    mold growth or decide to rely on your own judgment and common sense in 
    evaluating apparent mold growth. | 
  
    |  | Get estimates from at least three service providers. | 
  
    |  | Check references. | 
  
    |  | Ask the service provider whether he/she holds any relevant 
    state licenses. As of 1996, the following states require air duct cleaners 
    to hold special licenses: Arizona, Arkansas, California, Florida, Georgia, 
    Michigan and Texas. Other states may also require licenses. | 
  
    |  | Insist that the service provider give you knowledgeable and 
    complete answers to your questions. | 
  
    |  | Find out whether your ducts are made of sheet metal, flex 
    duct, or constructed of fiber glass duct board or lined with fiber glass 
    since the methods of cleaning vary depending on duct type. Remember, a 
    combination of these elements may be present. | 
  
    |  | Permit the application of biocides in your ducts only if 
    necessary to control mold growth and only after assuring yourself that the 
    product will be applied strictly according to label directions. As a 
    precaution, you and your pets should leave the premises during application. | 
  
    |  | Do not permit the use of sealants except under unusual 
    circumstances where other alternatives are not feasible. | 
  
    |  | Make sure the service provider follows the National Air 
    Duct Cleaning Association's (NADCA) standards and, if the ducts are 
    constructed of flex duct, duct board, or lined with fiber glass, the 
    guidelines of the North American Insulation Manufacturers Association (NAIMA). | 
  
    |  | Commit to a preventive maintenance program of yearly 
    inspections of your heating and cooling system, regular filter changes, and 
    steps to prevent moisture contamination. |